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This book is written in three parts. The first part, Modern HPLC Theory and Practice, covers the theory and current advances in HPLC retention mechanism; and the role of the column, mobile phase, and temperature in method selectivity and chromatographic retention including practical applications. The second part, HPLC in the Pharmaceutical Industry, discusses method development strategies and method validation at various stages of the drug development process with emphasis on GMP (Good Manufacturing Practices) requirements, including practical applications. The final part, Hyphenated Techniques and Specialized HPLC Separations, provides a selection of HPLC applications and methodologies.
HPLC for Pharmaceutical Scientists is an excellent handbook for both novice and experienced chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry.
Table of Contents
PREFACE.
CONTRIBUTORS.
PART I HPLC THEORY AND PRACTICE.
Introduction (Yuri Kazakevich and Rosario LoBrutto).
HPLC Theory (Yuri Kazakevich).
Stationary Phases (Yuri Kazakevich and Rosario LoBrutto).
Reversed-Phase HPLC (Rosario LoBrutto and Yuri Kazakevich).
Normal-Phase HPLC (Yong Liu and Anant Vailaya).
Size-Exclusion Chromatography (Yuri Kazakevich and Rosario LoBrutto).
LC/MS: Theory, Instrumentation, and Applications to Small Molecules (Guodong Chen, Li-Kang Zhang, and Birendra N. Pramanik).
Method Development (Rosario LoBrutto).
Method Validation (Rosario LoBrutto and Tarun Patel).
Computer-Assisted HPLC and Knowledge Management (Yuri Kazakevich, Michael McBrien, and Rosario LoBrutto).
PART II HPLC IN THE PHARMACEUTICAL INDUSTRY.
The Expanding Role of HPLC in Drug Discovery (Daniel B. Kassel).
Role of HPLC in Preformulation (Irina Kazakevich).
The Role of Liquid Chromatography--Mass Spectrometry in Pharmacokinetics and Drug Metabolism (Ray Bakhtiar, Tapan K. Majumdar, and Francis L. S. Tse).
Role of HPLC in Process Development (Richard Thompson and Rosario LoBrutto).
Role of HPLC During Formulation Development (Tarun S. Patel and Rosario LoBrutto).
The Role of HPLC in Technical Transfer and Manufacturing (Joseph Etse).
PART III HYPHENATED TECHNIQUES AND SPECIALIZED HPLC SEPARATIONS.
Development of Fast HPLC Methods (Anton D. Jerkovich and Richard V. Vivilecchia).
Temperature as a Variable in Pharmaceutical Applications (Roger M. Smith).
LC/MS Analysis of Proteins and Peptides in Drug Discovery (Guodong Chen, Yan-Hui Liu, and Birendra N. Pramanik).
LC-NMR Overview and Pharmaceutical Applications (Maria Victoria Silva Elipe).
Trends in Preparative HPLC (Ernst Kuesters).
Chiral Separations (Nelu Grinberg, Thomas Burakowski, and Apryll M. Stalcup).
CHEMICAL AND DRUG COMPOUND INDEX.
SUBJECT INDEX. ISBN 9788126528554
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Pages : 1136
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