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  Telomeres And Telomerase In Cancer (Hb)
 

Telomeres And Telomerase In Cancer (Hb)

by Keiko Hiyama

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  Telomeres and telomerase are the two pivotal players that determine the course of cellular sensecence and immortalization. A universal problem for all eukaryotic cells with linear chromosomes is telomere shortening due to "end-replication problems;" its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase-positive cells, and consequence of telomerase inhibition differ among species. Telomeres and Telomerase in Cancers, edited by Keiko Hiyama, focuses on human telomeres and telomerase, from their basic biology in normal human cells and cancer cells, to their clinical applications as diagnostic tools and therapeutic targets in anti-cancer strategies. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date research into the role of human telomeres and telomerase in cancerISBN - 9781603273060
 


Pages : 373
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