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Werner & Ingbar&rsquos The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunction&rsquos effects on other organ systems. Also addressed are clinical controversies regarding the aging thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy.
Salient Features
Twenty-three chapters authored by new contributors and international experts
A companion website with fully searchable text for quick reference
Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field.
Table of Contents
SECTION I: THE NORMAL THYROID
PART A: HISTORY, DEVELOPMENT, ANATOMY
The Heritage of the Thyroid: A Brief History
Development of the Hypothalamic&ndashPituitary&ndashThyroid Axis
Anatomy and Pathology of the Thyrotrophs
PART B: THYROID HORMONE SYNTHESIS AND SECRETION
A: Thyroid Hormone Synthesis: Thyroid Iodide Transport
B: Thyroid Hormone Synthesis
Thyroglobulin Structure, Function, and Biosynthesis
PART C : PERIPHERAL THYROID HORMONE BINDING AND METABOLISM
Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding
Intracellular Pathways of Iodothyronine Metabolism/Implications of Deiodination for Thyroid Hormone Action
PART D : THYROID HORMONE ACTION
Genomic and Nongenomic Actions of Thyroid Hormones
Thyroid Hormone Structure&ndashFunction Relationships
PART E : FACTORS THAT CONTROL THYROID FUNCTION
A: Chemistry and Biosynthesis of Thyrotropin
B: The Thyrotropin Receptor
C: Regulation of Thyrotropin Secretion
A: Age Related Changes in Thyroid Function
B: Effects of Drugs on TSH Secretion, Thyroid Hormones Absorption, Synthesis, Metabolism, and Action
C: Nonthyroidal Illness Syndrome
D: Iodine Deficiency and Endemic Cretinism
E: Effect of Excess Iodide: Clinical Aspects
SECTION II : ASSESSMENT OF THYROID STRUCTURE AND FUNCTION
Thyroid Radionuclide Uptake and Imaging Studies
A: Measuring Serum Thyroid&ndashStimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and Transport Proteins
B: Measurement of Thyroglobulin
Nonisotopic Techniques of Thyroid Imaging
Physical Examination of the Thyroid Gland
Pathology and Cytopathology
SECTION III : THYROID DISEASES: THYROTOXICOSIS
Introduction to Thyrotoxicosis
PART A : CAUSES OF THYROTOXICOSIS
A: Pathogenesis of Graves&rsquo Disease
B: Ophthalmopathy
C: Thyroid Dermopathy and Thyroid Acropachy
Thyrotropin-Induced Thyrotoxicosis
Toxic Adenoma and Toxic Multinodular Goiter
Trophoblastic Tumors
Sporadic Painless, Painful Subacute and Acute Infectious Thyroiditis
Thyrotoxicosis of Extrathyroid Origin
PART B : ORGAN SYSTEM MANIFESTATIONS
Overview of the Clinical Manifestations of Thyrotoxicosis
The Cardiovascular System in Thyrotoxicosis
Thyroid Hormones in Thermogenesis, Intermediary Metabolism, and Obesity
The Male and Female Reproductive System in Thyrotoxicosis
The Skeletal System in Thyrotoxicosis
Behavioral and Psychiatric Aspects of Thyrotoxicosis
Thyrotoxic Storm
PART C : DIAGNOSIS AND MANAGEMENT OF THYROTOXICOSIS
Diagnosis of Thyrotoxicosis
Treatment of Thyrotoxicosis
Subclinical Thyrotoxicosis
SECTION IV : THYROID DISEASES: HYPOTHYROIDISM
Introduction to Hypothyroidism
PART A : CAUSES OF HYPOTHYROIDISM
Chronic Autoimmune Thyroiditis
Genetic Defects Causing Hypothyroidism
Primary Hypothyroidism Due to Other Causes
Central Hypothyroidism
PART B : ORGAN SYSTEM MANIFESTATIONS OF HYPOTHYROIDISM
Overview of the Clinical Manifestations of Hypothyroidism
The Cardiovascular System in Hypothyroidism
The Male and Female Reproductive System in Hypothyroidism
The Skeletal System in Hypothyroidism
Psychiatric and Cognitive Effects of Hypothyroidism
Myxedema Coma
PART C : MANAGEMENT OF HYPOTHYROIDISM
Diagnosis of Hypothyroidism
Treatment of Hypothyroidism
Subclinical Hypothyroidism
SECTION V: THYROID DISEASES: NONTOXIC DIFFUSE AND MULTINODULAR GOITER
Multinodular Goiter: Pathogenesis and Management
Clinical Evaluation and Management of Thyroid Nodules
SECTION VI : THYROID CANCERS
A: Carcinomas of Follicular Epithelium: Epidemiology and Pathogenesis
B: Molecular Genetics of Tumors of Thyroid Follicular Cells
C: Carcinoma of the Follicular Epithelium: Surgical Therapy
D: Staging and Prognosis of Differentiated Thyroid Cancer
E: Medical Management of Differentiated Epithelial Cell Thyroid Cancer
Medullary Thyroid Carcinoma
Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid
SECTION VII : THE THYROID IN INFANCY AND CHILDHOOD
The Maturation of Thyroid Function in the Perinatal Period and During Childhood
A: Hypothyroidism in Infants and Children: Neonatal Screening
B: Hypothyroidism in Infants and Children: Congenital Hypothyroidism
C: Hypothyroidism in Infants, Children, and Adolescents: Acquired Hypothyroidism
Hyperthyroidism in the Neonatal Period and Childhood
SECTION VIII : SPECIAL TOPICS IN THYROIDOLOGY
Thyroid Disorders During Pregnancy and Postpartum
Thyroid Disruptors
Reduced Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and ActionISBN - 9788184738278
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Pages : 891
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